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Welcome to this video and I'm delighted to welcome Dr. William Mackus all the way from Alberta in Canada.

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Dr. Mackus, thank you so much for coming on.

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Thank you very much for having me.

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Now, we want to talk today about, well, matters of life and death, basically.

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Things of immense importance that aren't being discussed in mainstream media,

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that often aren't being discussed by regulatory agencies.

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In fact, things that often seem to be surrounded by a deafening silence, which is rather strange.

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Hopefully we can bring that up today.

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This is, of course, a purely academic discussion.

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We won't be making any medical recommendations or giving medical advice.

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That's between you and your own personal health care provider.

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But starters off, Dr. Mackus, if you like, just a little bit about yourself, your background.

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What professionally is your background? What do you do? What's your day job? That kind of thing.

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Certainly. I was born in communist Czechoslovakia and my family and I fled communism in 1988

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through a United Nations refugee camp in Yugoslavia.

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And so we were in a refugee camp for a year. This was before the Berlin Wall fell.

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And my father had been persecuted by the communist party in Czechoslovakia.

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He had been targeted as a university professor.

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They wanted him, of course, to promote communism and he did not want to.

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And so he felt the only option was to flee.

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And we were fortunate enough to be accepted by Canada.

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And so I grew up in Toronto, in Canada.

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I went to University of Toronto.

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I have a four-year undergraduate degree in immunology, then a four-year medical degree

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at McGill University in Montreal, and then a five-year specialization in nuclear medicine,

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radiology, and oncology, which is a branch of radiology, but it does have a very significant

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oncology component.

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And so my detractors will often say, well, Dr. Marcus, you're not an oncologist.

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What are you talking about?

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And I have oncology training.

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I've run oncology clinics for many years.

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And I have over 100 peer-reviewed publications in cutting-edge cancer diagnostics and cancer

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treatments.

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So that is my educational background.

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I worked in Alberta in a large cancer center.

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And then, unfortunately, as soon as Justin Trudeau's government was elected, my cancer program

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was targeted, sabotaged, and I had only learned later that the Trudeau government actually

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ended up copying my cancer program and my cutting-edge cancer work in another province in British

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Columbia for several hundred million dollars' worth of government funds.

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And the technology that I was working with was targeted radionuclide therapy, so targeted

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radiation.

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So you know, when cancer patients get radiation therapy, we refer to it often as external beam

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radiation therapy.

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It's external radiation.

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You're irradiating, you know, for example, breast cancer patients will have the area irradiated

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to make sure that they're killing any cancer cells that might have been left behind or any

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lymph nodes that are too small to be detected.

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And so I was working with targeted radiation that you inject.

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It's radiation that's attached to molecules or proteins that would deliver the radiation directly

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to the cancer and not irradiate healthy tissues.

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And so it was a much more advanced technology than external beam radiation.

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And unfortunately, the Trudeau government took it over.

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And you know, what's very interesting is that the Trudeau government in Canada was getting

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into pharmaceuticals.

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It was getting into the pharmaceutical industry, investing heavily into various cutting-edge

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technologies.

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And as we found out later, you know, that they would also invest into the mRNA vaccines as

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well.

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We have some mRNA vaccine factories being built in Canada.

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And so I've been involved in a legal battle with the provincial government here in Alberta

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about the sabotage of my cancer program.

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And so I was in a semi-retirement and in a legal battle when the pandemic hit.

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And really, that allowed me to be very objective about the nature of the pandemic and what I saw

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going on around me.

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And I think that objectivity I then brought to social media and platforms like X and like

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Substack.

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Indeed.

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Just before we go on, I was actually in Prague last year and I paid homage to the Yang Palach

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memorial in Wenceslas Square, who, of course, burnt himself to death after the Soviet invasion.

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Very moving.

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Very moving memorial.

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Still there and well visited by local people.

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It was good to see.

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Prague is one of the most beautiful, one of the most beautiful cities in the world and

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certainly sort of, it's sort of the heart of Europe in a way.

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Not only that, it's got fantastic beer.

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Yes.

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And it's cheap.

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Absolutely.

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So just to think a bit about the work that you were, you had, or what's the word I'm looking

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for?

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There's a word in academia.

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It begins with P, doesn't it?

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It sounds like major plagiarism.

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Of your work.

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You had some sort of radioactive molecule, something that gave off radiation.

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And that was hooked onto some molecule, presumably that had a high affinity for a cancer tissue.

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Exactly.

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That affinity molecule would then hook onto the cancer.

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And the molecule emitting the radiation would only be a molecule's distance away and would

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directly radiate the cancer.

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Have I got the essence of that correct?

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Exactly.

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Exactly.

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So the radioactive molecule would give off beta particles.

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It was chelated to a peptide that would deliver it directly to a receptor on the cancer cell.

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The half-life was six hours, so it was a short half-life.

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It would hit the cancer cell.

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It would render it enabled of replication, or it would damage the DNA of the cancer cell.

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Meanwhile, you wouldn't get any damage of the surrounding tissue.

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The patient would pee out the rest of the radiation, and it was done as an outpatient.

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They would get their injection, and then they would go home.

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Minimal side effects, and so I was a big fan of next-generation cancer treatments, more targeted

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cancer treatments, instead of the old-style chemotherapy where you would be hitting everything

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that was replicating rapidly, but you would also be hitting healthy tissue as well.

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In recent years, have you seen an increase in aggressive cancers, higher-grade cancers, cancers

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affecting younger people?

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What is sometimes called turbo-cancer, and is that a term you like?

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I have seen this, honestly, and I first saw this phenomenon in 2022.

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That was when I first realized that there's something else going on since the start of

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the pandemic that hadn't been properly characterized or looked at.

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I saw it among my colleagues, physician colleagues who were coming down, young colleagues who were

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coming down with these extremely aggressive cancers, and cancers that behaved unlike anything

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I had seen before, and I have seen that since.

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I've seen that in nursing.

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I've seen that among teachers, you know, these various professions that faced mandates at some

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point, and I'd seen this phenomenon, these very aggressive cancers, and they would kill

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the person very quickly.

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You know, they would kill a person in a matter of six months, and so the behavior was very

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different.

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I alerted the Canadian Medical Association of this in September of 2022.

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I had alerted them that I had seen a number of my physician's colleagues come down with

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these extremely aggressive cancers, and the term turbo-cancer started to be used around

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that time as well.

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It's not a term I like.

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I don't like the term turbo-cancer.

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It's not a medical term, and it's a term that, you know, someone who's sort of not aware

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of this phenomenon of these aggressive cancers may not take seriously.

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You know, it's a term that doesn't sound professional, but it's a term that I think really appropriately

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describes what I believe is a brand-new phenomenon in cancer, which is that some people are now

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developing extremely aggressive cancers that present at stage four.

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Usually, we're not catching them early on.

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We're catching them quite late.

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Stage three, stage four presentations.

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Young people, these are shocking.

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When you see young women in their 20s present with stage four breast cancer, and they have

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no family history, and they have no genetic markers that you can detect, no BRCA1 or 2

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mutation, that's when you realize that something is really wrong here.

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Colon cancers presenting in young people in their 20s and 30s.

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We shouldn't be seeing that.

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You know, I always refer to the case of cholangiocarcinomas.

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Cholangiocarcinomas, these are bile duct cancers where the average age was 70, the average age

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of presentation.

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This is a cancer of the elderly, and yet we have 20, 25-year-olds presenting with stage

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four cholangiocarcinomas, something that I'd never seen in my career.

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And so there is something new happening.

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The term turbocancer has stuck.

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I believe it appropriately describes the very aggressive nature of these cancers.

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They grow very rapidly.

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They metastasize and spread.

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So even when surgeons are trying to go in and get the primary tumor out, by the time

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they re-scan the patient after the surgery, they realize it has already spread to multiple

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organs and they didn't catch it in time.

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That's how quickly this thing moves.

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And one particular feature of it, which I think is very shocking but very characteristic,

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is these cancers are resistant to conventional chemotherapy, conventional radiotherapy, and

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even conventional immunotherapy.

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And so you see this very shocking resistance to chemotherapy.

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And so you will get either no response or partial response.

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The oncologists really struggle with these cancers, these turbo cancers.

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They struggle with them because they throw everything at it.

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You know, the oncologists are genuinely trying to get these cancers under control as they used

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to in the past.

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And so imagine, you know, you would have a breast cancer patient who could live another

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five years, ten years with conventional treatment.

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And then that patient dies six months later.

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And you're left wondering, what is going on?

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Why are these patients dying so soon after diagnosis?

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Why are they resistant to conventional treatment?

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And that's just not being looked at.

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It's not being studied.

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It's really being ignored by mainstream oncology.

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And so Professor Deglish, for example, talks about this.

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You know, he has noticed this phenomenon in the last few years as well.

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And the pathologists, you know, I'm really proud of my pathology colleagues like Dr. Ryan

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Cole, Dr. Professor Burkhardt in Germany, who've really been, you know, raising the alarm about

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this telling us there is something wrong here.

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These terrible cancers are real and they are claiming thousands of young lives and no one

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is studying it.

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No one is looking into it.

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It almost sounds like a new pathology, doesn't it?

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I mean, you know, tragically in clinical practice, we've seen young cancers.

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We've seen childhood cancers.

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But very often, young adult cancers are associated with a specific mutation or genetic disorder.

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You mentioned there the BRCA1 or 2 mutation, which predisposes to tragically early life breast

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cancer, ovarian cancer.

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But now we're seeing cancers of an aggressive nature in young people without these genetic

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mutations.

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That's right.

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It's almost like a new pathology.

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And the fact that it's they seem to be resistant to existing treatments, again, is indicating a

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new pathology, really.

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I want to talk about that a bit.

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But just before that, you mentioned stage three and four there.

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We talk about this a lot.

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Just run us very briefly through, if you don't mind.

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What is stage one, two, three, four cancer?

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Well, so the stages represent the really the size and extent of the tumors.

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And so if if we think breast cancer as an example, stage one would be a small tumor, one centimeter,

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two centimeter.

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Then stage two would be a larger tumor.

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And and then usually you often have spread to local lymph nodes.

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And then that'll be stage two.

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Stage three, you might get spread to further lymph nodes.

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It's now you're not you're not in the local area of the tumor anymore.

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You start spreading to more distant lymph nodes.

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And then stage four, of course, you get spread to other organs like liver, bones, brain and so on.

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And so each cancer has its own staging system.

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Stages one to four that describe the size of the primary tumor and the spread to the surrounding.

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It starts, you know, usually spread to surrounding lymph nodes and then eventually spread to other organs as well.

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When we talk about stage four, we're talking about metastatic disease.

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There'll be the cancer will be in the primary site.

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It will probably have grown and expanded in the primary site, but it'll have metastasized spread to distant parts.

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One or more distant parts of the body, making it much harder to treat, presumably.

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Exactly.

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And I think I want to go back to this idea, and you'd mentioned that it almost looks like a new pathology.

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Please.

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And I do believe that we are dealing with a brand new pathophysiology.

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We're not we're not dealing with just cancers that are more aggressive.

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We're dealing with something brand new, something that has a new mechanism by which it's arising.

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And I believe, you know, again, this is where the pathologists come in.

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And, you know, like Dr. Ryan Cole, Professor Burkhardt, where they're trying to look at these tumors and see what's different about these tumors,

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what's different about the patients who develop these cancers.

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And so we are dealing with something new.

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And another marker or another feature of these turbo cancers that I find fascinating that has come up over and over,

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and really no one talks about it, is that oncologists tend to be very good at giving you a proper prognosis.

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And so when you come in and you're a certain type of breast cancer patient, let's say stage four, you know,

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we know that you are, you know, hormone positive, for example.

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The oncologist is very good at giving you a prognosis.

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Saying, look, if you follow, you know, the conventional treatments, we know you're going to live another five years or ten years or three years,

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whatever the case may be.

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And so the prognostication in oncology is quite good.

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My oncology colleagues are really quite good.

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And this is based on studies of hundreds of thousands of people.

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Usually these are the large trials that they look at when they offer conventional treatments to patients.

236
00:15:13,200 --> 00:15:16,740
Well, this is where they've been completely off.

237
00:15:17,580 --> 00:15:25,180
And you will see this, you will see this thousands of cases on GoFundMe where families of cancer patients are raising funds

238
00:15:25,180 --> 00:15:30,300
and they will share the medical story of the person who's been affected by a terrible cancer.

239
00:15:30,800 --> 00:15:36,180
And they will say, the oncologist told us we had five years and our loved one died within two, three months.

240
00:15:36,620 --> 00:15:42,600
I have never seen my oncology colleagues be off by a factor of ten in prognostication.

241
00:15:42,600 --> 00:15:43,800
I have never seen that.

242
00:15:44,000 --> 00:15:45,860
You don't get it that wrong.

243
00:15:47,340 --> 00:15:50,660
You know, or colon cancer, for example, where you could live another five years

244
00:15:50,660 --> 00:15:54,040
and then the person, again, dies two, three months later after diagnosis.

245
00:15:54,180 --> 00:15:58,340
And it catches the oncologist off guard and it catches the family off guard.

246
00:15:58,740 --> 00:16:03,420
Because they've told the family, you know, we can with conventional treatments,

247
00:16:03,520 --> 00:16:07,540
you'll have at least another two years, three years, five years, and the person dies a few months later.

248
00:16:07,540 --> 00:16:12,500
That shocks everybody and that throws everybody off.

249
00:16:12,600 --> 00:16:19,520
And so why are my colleagues now off in their prognostication by a factor of five to ten?

250
00:16:20,060 --> 00:16:21,220
There's something wrong here.

251
00:16:21,360 --> 00:16:24,340
I believe we are dealing with a brand new pathophysiology.

252
00:16:24,340 --> 00:16:28,440
I believe it's something that should be seriously looked at.

253
00:16:28,440 --> 00:16:34,180
And unfortunately, we're stuck in the situation where some of my colleagues who are seeing this,

254
00:16:34,280 --> 00:16:36,680
like Professor Deglish, for example, we will look at the literature.

255
00:16:37,040 --> 00:16:41,100
We will look at the published literature and understand that there are dozens of papers

256
00:16:41,100 --> 00:16:46,400
that are looking at aggressive cancers and, you know, the manner by which they may be arising.

257
00:16:46,400 --> 00:16:48,800
And there are case reports and so on.

258
00:16:49,020 --> 00:16:56,540
And yet, on the other hand, when, you know, you'll have doctors in the mainstream and in academia saying,

259
00:16:56,680 --> 00:16:58,100
well, there's no such thing as turbo cancer.

260
00:16:58,100 --> 00:17:01,240
And when you put it in the search engine, no literature comes up.

261
00:17:01,380 --> 00:17:06,440
And you have Wikipedia, which will say turbo cancer is a conspiracy theory.

262
00:17:06,600 --> 00:17:08,960
It's an alternative medicine, fringe medicine.

263
00:17:09,220 --> 00:17:10,600
It doesn't exist, right?

264
00:17:10,860 --> 00:17:12,040
It's not a thing.

265
00:17:12,120 --> 00:17:12,780
It doesn't exist.

266
00:17:13,260 --> 00:17:14,600
And that's not science.

267
00:17:14,600 --> 00:17:16,280
You know, that's not science.

268
00:17:16,460 --> 00:17:22,040
When you have a phenomenon in front of you to say this doesn't exist, this is not happening,

269
00:17:22,240 --> 00:17:27,420
and this is not real, and cancers are not increased, and, you know, cancers are unchanged,

270
00:17:28,020 --> 00:17:32,540
to deny a phenomenon, you know, that's right in front of your face and where you have thousands of cases

271
00:17:32,540 --> 00:17:38,280
with families coming to social media saying, yes, this happened to us, that's not science.

272
00:17:38,420 --> 00:17:39,720
That's not how science should work.

273
00:17:40,020 --> 00:17:41,240
It is quite bizarre, isn't it?

274
00:17:41,320 --> 00:17:44,340
It is denial of that which is patently obvious.

275
00:17:44,340 --> 00:17:46,380
It's a bit like saying Australia doesn't exist.

276
00:17:46,520 --> 00:17:51,060
I mean, it's, you know, we're into the realms of incredulity here, really.

277
00:17:51,300 --> 00:17:57,220
It's, so you mentioned these accelerated cancers, turbo cancers for want of a better term.

278
00:17:58,280 --> 00:18:05,200
Are we seeing like a group of turbo cancers and a group of what you might call traditional cancers as well?

279
00:18:05,200 --> 00:18:10,120
So are we seeing a group of cancers that still carried on where the oncologists are still getting it right?

280
00:18:10,920 --> 00:18:11,440
Absolutely.

281
00:18:11,920 --> 00:18:14,060
So kind of get two streams of cancers, really.

282
00:18:14,740 --> 00:18:15,880
Exactly, exactly.

283
00:18:16,060 --> 00:18:17,760
And so I see both.

284
00:18:17,920 --> 00:18:18,980
I see both.

285
00:18:18,980 --> 00:18:27,360
I see your typical cancers where a patient has been struggling with stage 4 breast cancer, and they've been struggling for years.

286
00:18:27,360 --> 00:18:34,280
They've been struggling for years, but, you know, they go to various chemotherapies and immunotherapies, and they're effective for a while.

287
00:18:34,360 --> 00:18:36,820
And then at some point, you know, they're not effective anymore.

288
00:18:36,820 --> 00:18:43,320
They get a bit of progression of disease, but they've had stage 4 for four or five years, and they're still battling it.

289
00:18:44,020 --> 00:18:48,660
And then you have, you know, a similar situation where a stage 4 breast cancer patient will come in.

290
00:18:49,580 --> 00:18:51,960
You know, this cancer is growing extremely rapidly.

291
00:18:52,380 --> 00:18:53,480
Nothing seems to work.

292
00:18:53,940 --> 00:18:58,620
Anything that the oncologist tried, nothing seems to be working, and then they pass away after a few months.

293
00:18:58,720 --> 00:19:01,140
And so both of these are going on at the same time.

294
00:19:01,780 --> 00:19:04,060
And it is confusing.

295
00:19:04,060 --> 00:19:13,860
I think if you're not open to the idea that something has changed in the last few years where we might be seeing a brand-new pathophysiology,

296
00:19:13,980 --> 00:19:19,940
whatever the reason behind it may be, if you're not open to the idea that something has drastically changed in the last few years

297
00:19:19,940 --> 00:19:27,100
where you have this subset of cancers that are behaving completely differently, then I think you will be caught.

298
00:19:27,100 --> 00:19:35,080
But if you're in medicine and you're not open to this, I think you'll be completely caught off guard.

299
00:19:36,020 --> 00:19:38,300
Which seems to be happening on a huge scale.

300
00:19:38,420 --> 00:19:39,880
I think it has to be said at the moment.

301
00:19:40,860 --> 00:19:50,280
Now, what sort of, if we reluctantly use this term, turbo cancer, what sort of primary sites are we seeing?

302
00:19:50,280 --> 00:19:52,320
Where are these cancers originating?

303
00:19:52,980 --> 00:19:55,700
And is there a typical sort of metastatic pattern?

304
00:19:55,860 --> 00:19:58,420
So, for example, in the colon, you would expect it to go to the liver.

305
00:19:59,780 --> 00:20:02,260
If the prostate, you might expect it to go to the bone.

306
00:20:03,300 --> 00:20:08,800
So, first of all, what sort of primary sites are we seeing with what we could call turbo cancers?

307
00:20:08,800 --> 00:20:18,140
There have been articles published, I believe there was one published by Memorial Sloan Kettering Cancer Center in the United States

308
00:20:18,140 --> 00:20:26,440
that talked about a wide variety of cancers that have sort of exploded recently and are affecting young people.

309
00:20:26,500 --> 00:20:28,740
So, it's not one type of cancer, one or two types of cancer.

310
00:20:29,200 --> 00:20:38,260
I'm seeing an explosion of lymphomas, brain cancers that are even more aggressive than what we were used to in the past.

311
00:20:38,260 --> 00:20:41,060
Breast cancers, the big ones are breast and colon.

312
00:20:41,740 --> 00:20:53,700
Breast and colon, and I can tell you, in fact, how the mainstream medicine and oncology are reacting to this explosion of breast cancers and colon cancers in a much younger cohort.

313
00:20:54,560 --> 00:21:03,760
And so, I do believe that this new pathophysiology affects all ages, but when you see it in a younger cohort, people in their 20s and 30s,

314
00:21:03,860 --> 00:21:06,740
that's when you say, wait a minute, something's really, really wrong here.

315
00:21:06,740 --> 00:21:11,940
This is not a cohort that should be presenting with stage 4 breast cancers or colon cancers.

316
00:21:12,880 --> 00:21:18,600
And so far, the response of mainstream oncology has been to lower the screening age.

317
00:21:18,640 --> 00:21:23,020
And so, we've seen this in the United States, and we've seen this in Canada.

318
00:21:23,100 --> 00:21:31,040
And I don't know about the UK, to be honest, but the screening age for breast cancer has already been lowered from 50 to 40.

319
00:21:31,040 --> 00:21:35,720
Not as far as I'm aware in the UK, but it's interesting that's happening in the States and Canada.

320
00:21:36,500 --> 00:21:38,280
Yeah, that has already happened.

321
00:21:38,700 --> 00:21:43,020
The screening age has been lowered for breast cancer from 50 to 40 for mammography.

322
00:21:43,020 --> 00:21:51,380
And now there's significant debate going on about decreasing the screening age for colon cancer.

323
00:21:51,880 --> 00:21:54,920
And then the debate is, well, what age are we lowering it to?

324
00:21:55,140 --> 00:21:59,280
Are we lowering it from 50 to 40 or even to 30, you know, to have that?

325
00:21:59,280 --> 00:22:04,200
Yeah, it's still 60 in the UK for fecal or colon blood screening.

326
00:22:04,200 --> 00:22:10,360
And so, and again, this doesn't get a lot of attention or it doesn't get a lot of, you know, media attention

327
00:22:10,360 --> 00:22:18,600
because I think the cancer centers themselves can't make, you know, they don't know what to make of this situation with these turbo cancers.

328
00:22:18,900 --> 00:22:24,820
But, and so they talk about lowering the screening age, but we should be finding out what the pathophysiology is.

329
00:22:25,180 --> 00:22:28,180
We should be looking at these cases specifically.

330
00:22:28,360 --> 00:22:29,520
We should be analyzing them.

331
00:22:29,520 --> 00:22:38,240
I mean, pathology is the specialty, you know, that could look at these tumors in detail, analyze them and see what is different about these tumors

332
00:22:38,240 --> 00:22:44,800
that is causing such a rapid progression and such poor prognosis.

333
00:22:45,360 --> 00:22:46,540
Well, that's why we have pathologists.

334
00:22:46,680 --> 00:22:49,040
That's why they're useful people to have, to do pathology.

335
00:22:49,300 --> 00:22:51,400
So it's fairly obvious.

336
00:22:51,800 --> 00:22:53,920
So, I mean, I take your point there entirely.

337
00:22:53,920 --> 00:23:01,140
So 72-year-old woman gets turbo cancer for the breast, breast cancer is common at that age anyway.

338
00:23:01,300 --> 00:23:03,800
22-year-old woman, it kind of stands out.

339
00:23:03,880 --> 00:23:05,680
It's more of an obvious outlier.

340
00:23:05,840 --> 00:23:08,700
But you believe it's occurring at all ages.

341
00:23:09,080 --> 00:23:11,660
I do see it in all ages, exactly.

342
00:23:11,940 --> 00:23:13,120
And you're absolutely right.

343
00:23:13,160 --> 00:23:17,900
When it happens in someone who's in their, you know, 60s, 70s, 80s, you don't pay as much attention to it.

344
00:23:17,900 --> 00:23:24,040
And you say, well, you know, cancer is much more common in these age groups and it doesn't catch, it doesn't catch your attention.

345
00:23:24,420 --> 00:23:25,340
It doesn't stand out.

346
00:23:25,540 --> 00:23:37,420
And yet when you see a 20-year-old, and I've seen, I've seen women as young as 18, 19, presenting with stage four breast cancer with no family history and no genetic markers to go on.

347
00:23:37,720 --> 00:23:43,280
And if that isn't a red flag or an alarm bell for the medical community and for oncologists, I don't know what is.

348
00:23:43,280 --> 00:23:47,440
I mean, that is unheard of unless you're in a post-Hiroshima situation.

349
00:23:47,680 --> 00:23:48,900
I mean, it's just unheard of, isn't it?

350
00:23:48,980 --> 00:23:50,740
It just doesn't happen.

351
00:23:51,680 --> 00:23:52,000
Absolutely.

352
00:23:52,280 --> 00:23:52,460
Yeah.

353
00:23:52,880 --> 00:23:55,560
Now, I want to think about temporal correlations.

354
00:23:56,000 --> 00:23:58,640
You started noticing this early 2022.

355
00:24:00,340 --> 00:24:09,660
So what possible changes could there have been in the environment in the years before that?

356
00:24:09,660 --> 00:24:13,300
And what do you suspect the lag period might be?

357
00:24:13,520 --> 00:24:17,060
So, for example, we had COVID in 2020.

358
00:24:17,400 --> 00:24:19,920
We had COVID vaccines in 2021.

359
00:24:21,280 --> 00:24:35,040
If we postulate that this is a post-COVID, post-vaccine event, do you think that one or two years is a significant lead time for the pathological changes induced potentially by COVID infection or by vaccination?

360
00:24:35,040 --> 00:24:40,340
Is that enough for that to transpose into the overt pathologies that you're seeing?

361
00:24:40,340 --> 00:24:56,280
Well, I think this is where I think the discussion gets quite heated because you will have people saying, well, you know, if someone develops an extremely aggressive cancer, maybe they had a COVID infection a few months before.

362
00:24:56,460 --> 00:24:58,320
Maybe they had a vaccination.

363
00:24:59,320 --> 00:25:05,700
And you will have people saying, well, that's not enough time, you know, for an aggressive colon cancer to arise.

364
00:25:05,700 --> 00:25:10,080
You know, a colon cancer takes many years to develop or even a breast cancer.

365
00:25:10,320 --> 00:25:15,420
And yet I am seeing some of these temporal correlations in some cases.

366
00:25:16,120 --> 00:25:21,060
But in some cases, you know, this cancer will arise years later.

367
00:25:22,020 --> 00:25:27,080
And so there's not a clear picture of a temporal correlation.

368
00:25:27,080 --> 00:25:40,360
But, you know, you bring up the point of what has what has changed in the last few years that could be contributing to this, you know, to this dramatic rise and this potentially new pathophysiology.

369
00:25:40,360 --> 00:25:52,960
And I really think, you know, you've got these two main things that have happened in the last four or five years is we have this COVID virus, this somewhat novel virus.

370
00:25:53,960 --> 00:25:57,760
And we had a pandemic with multiple waves of infections.

371
00:25:58,900 --> 00:26:07,000
You know, this is not a one-time thing where you could say, well, you know, we had one wave of COVID-19.

372
00:26:07,000 --> 00:26:10,540
We've had multiple waves, unfortunately, we've had different variants.

373
00:26:10,680 --> 00:26:13,480
You know, we've had Delta variant, you know, the various Omicron variants.

374
00:26:14,000 --> 00:26:18,740
And then then also we've had we've had the COVID-19 vaccines and different types as well.

375
00:26:18,880 --> 00:26:20,420
You know, we had the DNA based vaccines.

376
00:26:20,520 --> 00:26:22,200
We have the mRNA based vaccines.

377
00:26:23,060 --> 00:26:35,160
And so these are things that that are different, that that have affected a large segment of the population in one way or another in the last four years, let's say.

378
00:26:35,160 --> 00:26:39,740
And so I think it's worth looking at looking at those things.

379
00:26:41,000 --> 00:26:52,740
But but, you know, it seems to be somewhat of a of a taboo subject, particularly because there's this, you know, there's this overall desire of people to just move on.

380
00:26:52,880 --> 00:26:54,820
People want to move on from the COVID pandemic.

381
00:26:54,820 --> 00:27:00,480
And they don't want to talk about they don't want to talk about what's happened in the last few years.

382
00:27:00,480 --> 00:27:05,320
But I've really I really noticed this phenomenon in 2022, in the summer of 2022.

383
00:27:05,680 --> 00:27:13,420
But I could trace back some of these extremely aggressive cancers to 2021 as well.

384
00:27:13,420 --> 00:27:27,340
And when some of some of my colleagues were being diagnosed with these extremely aggressive cancers, these turbo cancers in 2021 and and really no one realized that there was anything different about these cancers.

385
00:27:27,340 --> 00:27:29,200
And they would die six months later.

386
00:27:29,200 --> 00:27:32,700
And, you know, people would say, well, that's unfortunate.

387
00:27:32,960 --> 00:27:33,800
You had bad luck.

388
00:27:35,500 --> 00:27:36,240
It's OK.

389
00:27:36,380 --> 00:27:39,020
Well, you could have bad luck in a few cases.

390
00:27:39,160 --> 00:27:45,400
But when it's happening, when it when you have thousands of cases of bad luck, that's when science has to come in.

391
00:27:45,880 --> 00:27:49,060
That's when you have to investigate and you have to investigate with an open mind.

392
00:27:49,060 --> 00:27:55,320
You have to look at all the possibilities, you know, could could there be something from a COVID infection that might be contributing?

393
00:27:55,540 --> 00:27:56,440
It's very possible.

394
00:27:56,620 --> 00:27:58,540
Could it be something from the COVID vaccine?

395
00:27:58,600 --> 00:28:00,240
That's also very possible as well.

396
00:28:00,600 --> 00:28:05,820
We have to approach this with with an open mind and look at all and look at those possibilities.

397
00:28:06,780 --> 00:28:12,520
And and yet those of us who are raising the concerns, raising the questions, you know, we get attacked, we get censored.

398
00:28:12,640 --> 00:28:16,040
I was censored for about a year off the Twitter platform.

399
00:28:16,040 --> 00:28:22,560
I only started my sub stack where I published a lot of articles talking about this phenomenon.

400
00:28:23,440 --> 00:28:29,220
I started my sub stack in early 2023 because I wasn't being allowed back on the Twitter platform.

401
00:28:29,340 --> 00:28:31,420
I thought I would never get my Twitter account back.

402
00:28:31,540 --> 00:28:39,460
And fortunately, Elon Musk bought the entire platform for forty four billion dollars and brought a number of us, you know, physicians back like Dr.

403
00:28:39,520 --> 00:28:40,460
Robert Malone, Dr.

404
00:28:40,520 --> 00:28:41,420
Peter McCullough, Dr.

405
00:28:41,500 --> 00:28:42,680
Pierre Corey and Dr.

406
00:28:42,740 --> 00:28:43,700
Ryan Cole and so on.

407
00:28:43,820 --> 00:28:44,800
Donald Donald Trump.

408
00:28:44,800 --> 00:28:46,040
Exactly.

409
00:28:46,260 --> 00:28:47,320
So it could be mentioned.

410
00:28:48,040 --> 00:28:58,340
I, you know, I feel blessed and fortunate to have my voice back because in 2022, when I was raising these concerns, I was writing letters to the Canadian Medical Association.

411
00:28:58,340 --> 00:28:59,200
I was being ignored.

412
00:28:59,460 --> 00:29:01,240
I didn't have a social media platform.

413
00:29:01,240 --> 00:29:18,180
So I was effectively censored during a time when I was trying to raise concerns about turbo cancer, about this new pathophysiology that was affecting people, you know, these stage four cancers that no one can quite explain why they behave the way they behave.

414
00:29:18,180 --> 00:29:19,580
I didn't have a platform.

415
00:29:19,580 --> 00:29:21,260
I was completely censored at the time.

416
00:29:21,720 --> 00:29:23,060
You were being censored at the time.

417
00:29:23,140 --> 00:29:26,040
We most needed people with your expertise and your background.

418
00:29:26,220 --> 00:29:29,880
It really is quite paradoxical and bizarre.

419
00:29:29,880 --> 00:29:43,820
My simplified way of looking at this, if there is a new pathophysiology here, then it's not unreasonable to say that there could be an accelerated oncogenesis, you know, an accelerated development of cancer.

420
00:29:44,240 --> 00:29:47,280
I mean, you know, very often with cancer, we think about a long progression.

421
00:29:47,280 --> 00:29:52,640
There might be changes in tissue, so-called metaplasia before the malignant change.

422
00:29:52,720 --> 00:29:54,620
There might be multi-hit ideas.

423
00:29:55,420 --> 00:30:05,940
If we're dealing with what we might call a complete carcinogen, an initiator and a promoter that can do both things really quite quickly.

424
00:30:06,620 --> 00:30:14,380
It's not ludicrous to me at all that someone could have no pathophysiological changes, no anatomical changes.

425
00:30:14,380 --> 00:30:21,860
But be exposed to an initiator and promoter of cancer and develop clinical pathology within a year.

426
00:30:21,940 --> 00:30:28,340
I find that quite credible based on my limited experience and understanding of the pathology.

427
00:30:29,020 --> 00:30:29,420
Absolutely.

428
00:30:29,820 --> 00:30:33,100
So that's definitely, I think, a component of this.

429
00:30:33,760 --> 00:30:42,760
Another component that I think is relevant is the state of a person's immune system.

430
00:30:42,760 --> 00:30:49,860
And so, you know, when we have something that impacts a person's immune system dramatically.

431
00:30:50,000 --> 00:30:56,040
Now, we see this in AIDS and HIV patients who have HIV infections.

432
00:30:56,040 --> 00:31:01,700
They develop some very aggressive cancers because their immune system is compromised.

433
00:31:01,700 --> 00:31:12,520
And I think, again, we've been in a situation in the last four years where people's immune systems have been compromised, whether they were compromised by a virus or a vaccine.

434
00:31:13,160 --> 00:31:19,700
I think we see a lot of people who are struggling, people who are struggling with infections.

435
00:31:19,700 --> 00:31:21,180
They get repeated infections.

436
00:31:21,320 --> 00:31:25,280
They get repeated COVID infections or they may get repeated influenza infections.

437
00:31:25,280 --> 00:31:28,280
I have seen an explosion of strep.

438
00:31:28,900 --> 00:31:43,160
I have seen an explosion of sepsis and young, healthy people dying of these things, young, healthy people dying of influenza, young, healthy people dying of strep throat and septicemia and septic shock.

439
00:31:43,160 --> 00:31:51,420
And so I do believe that a compromised immune system, you know, may play a role in some of these cases.

440
00:31:52,020 --> 00:31:55,740
And we don't have a good way of measuring a compromised immune system.

441
00:31:55,860 --> 00:32:01,480
Someone whose immune system has been damaged in some way, we don't have a great way of measuring.

442
00:32:01,620 --> 00:32:06,140
And, you know, we measure the CD8 and CD4 cells in AIDS patients.

443
00:32:06,140 --> 00:32:07,740
The white blood cell profile.

444
00:32:07,740 --> 00:32:08,640
So exactly.

445
00:32:08,860 --> 00:32:15,460
But but we don't have a good way of measuring, you know, if someone's immune system has been compromised in some way.

446
00:32:15,600 --> 00:32:20,880
And so I think that also also plays a factor in some of these cases.

447
00:32:21,500 --> 00:32:32,620
I suspect personally that the coronavirus was not the cause of these turbo cancers because we've been exposed to different coronaviruses for a long time.

448
00:32:32,620 --> 00:32:35,120
OK, this one was quite novel.

449
00:32:35,180 --> 00:32:38,200
It had some unusual features that are difficult to explain.

450
00:32:38,300 --> 00:32:43,240
There's no obvious predecessor in the natural world for this particular one.

451
00:32:43,240 --> 00:32:45,880
But at the end of the day, it's still a coronavirus.

452
00:32:47,320 --> 00:32:59,440
And the small components of that, the bits that the immune system recognizes, what we call the epitopes of that, a lot of those would already be somewhat familiar to the immune system.

453
00:32:59,440 --> 00:33:07,280
So I suspect we're looking at something other than the coronavirus that occurred in 2021.

454
00:33:08,820 --> 00:33:13,600
That seems to be the Occam's razor, if you like.

455
00:33:14,820 --> 00:33:15,340
I think so.

456
00:33:15,540 --> 00:33:23,840
And I think and the other part of it is is also looking at, you know, populations that that are affected.

457
00:33:23,840 --> 00:33:32,060
I see, you know, university students, college students who've been impacted by turbo cancers.

458
00:33:32,900 --> 00:33:41,340
I've seen certain professions, doctors, nurses, teachers, police officers, firefighters, military.

459
00:33:41,620 --> 00:33:45,480
And so, you know, you have to ask the question, well, why?

460
00:33:45,480 --> 00:33:48,060
Why are we seeing this in certain groups?

461
00:33:48,280 --> 00:33:55,540
You know, there there were there were mandates in some of these groups, especially in 2021.

462
00:33:56,540 --> 00:34:04,120
You know, we had we had mandates that affected a lot of these people, a lot of young people or some of these professions in health care, for example.

463
00:34:04,280 --> 00:34:10,360
We had health care workers who who faced mandates as well and the entire profession faced it.

464
00:34:10,360 --> 00:34:21,560
So I think it's definitely something that that we have to look at and and really consider a possibility where where where there were mandates.

465
00:34:22,520 --> 00:34:25,680
You know, is that something that contributed to this phenomenon?

466
00:34:26,300 --> 00:34:35,340
And to understand that we really need full data release and release of primary source data that in the UK, at least, we simply don't have access to.

467
00:34:35,340 --> 00:34:41,520
So I'm optimistic that in the United States, this data can be made available.

468
00:34:41,680 --> 00:34:55,600
Now, I've talked to people who know about this and they assure me categorically that this data can be completely anonymized and yet is amenable to very rigorous, quantitative analysis.

469
00:34:56,720 --> 00:35:00,420
So and when we're dealing with millions of people.

470
00:35:01,080 --> 00:35:03,100
Yes, we have that opportunity in the United States.

471
00:35:03,100 --> 00:35:08,500
It's I and, you know, and I and I don't see I don't see this opportunity in Canada, for example.

472
00:35:08,500 --> 00:35:16,960
I know there's been no transparency from whether it's the federal government or the provincial governments that are responsible for health care.

473
00:35:17,080 --> 00:35:24,480
If anything, you know, I had actually started my sub stack with a series on of articles on how the government was deleting data,

474
00:35:24,480 --> 00:35:38,540
crucial data from the government websites where where people could could no longer make an informed decision in terms of their own personal health because the government was either hiding or deleting data outright.

475
00:35:38,540 --> 00:35:48,180
So I think, you know, there's a very unique opportunity now in the United States with RFK Junior being confirmed, which I believe he will be confirmed.

476
00:35:48,180 --> 00:35:56,680
And I think he's expressed a strong desire to to look into this and really a strong desire for transparency in science.

477
00:35:56,780 --> 00:36:01,440
And that's what we need. We need transparency in science to do proper science across the whole field.

478
00:36:01,440 --> 00:36:12,700
Well, this is just one particular example, really, but let's hope there's been no data accidentally deleted in the United States in the past in the past few weeks.

479
00:36:12,800 --> 00:36:14,620
Let's hope that is is the case.

480
00:36:15,260 --> 00:36:15,580
Dr.

481
00:36:15,620 --> 00:36:17,440
Markers, that's absolutely fascinating.

482
00:36:17,440 --> 00:36:20,100
I've let that run a while to unpack that.

483
00:36:20,180 --> 00:36:21,840
I think that's really well worth doing.

484
00:36:22,640 --> 00:36:26,000
Absolutely important to document that.

485
00:36:26,480 --> 00:36:32,380
But we do want to go on and talk about novel approaches to treatment to treating cancers.

486
00:36:32,380 --> 00:36:42,080
And particularly, I want to talk about repurposed drugs, drugs with a known safety profile, very often very safe.

487
00:36:42,080 --> 00:36:52,680
Drugs that have been used for decades, drugs that have been used on, without exaggeration, in the case of ivermectin, billions of people.

488
00:36:54,120 --> 00:36:55,960
Drugs which are very cheap.

489
00:36:56,760 --> 00:37:06,080
Drugs which can be manufactured literally by the tonne, relatively cheaply because they're often fairly simple molecules.

490
00:37:06,080 --> 00:37:13,540
Drugs and drugs which may well be highly efficacious against the disease they were originally designed for or developed for or isolated for.

491
00:37:14,580 --> 00:37:23,580
But then out of lucky accidents, really, serendipitously, are amenable to treating other conditions.

492
00:37:24,000 --> 00:37:25,880
And we have we have a lot of precedent for this.

493
00:37:26,060 --> 00:37:29,780
So aspirin, for example, from willow bark was initially used for treating fevers.

494
00:37:29,780 --> 00:37:38,260
Now we realize it reduces platelet viscosity and help can prevent blood clotting and various other anti-inflammatory things.

495
00:37:38,360 --> 00:37:39,520
So this is not unique.

496
00:37:39,680 --> 00:37:41,880
This has happened quite a few times.

497
00:37:42,600 --> 00:37:51,040
I mean, there was a drug introduced for for treating myocardial ischemia for angina.

498
00:37:51,040 --> 00:37:56,460
And it was later used for treating impotence as a surprise as a surprise finding.

499
00:37:56,720 --> 00:37:58,040
So this isn't this isn't unusual.

500
00:37:58,240 --> 00:38:04,380
But what first arose your interest in repurposed drugs in the field of oncology?

501
00:38:06,380 --> 00:38:12,620
I I've started getting into repurposed drugs in when I started my sub stack in early 2023.

502
00:38:12,620 --> 00:38:26,180
And I really wanted to do a deep dive into early treatments for covid-19 treatments such as ivermectin, hydroxychloroquine.

503
00:38:26,600 --> 00:38:31,660
And I wanted to know for myself, you know, you know, were these were these effective in covid-19?

504
00:38:31,780 --> 00:38:32,100
Were they not?

505
00:38:32,180 --> 00:38:33,060
What was the science?

506
00:38:33,320 --> 00:38:35,200
What was what was the research telling us?

507
00:38:35,440 --> 00:38:41,060
And and of course, you know, when you whenever you want to do a deep dive into a topic like that, you have to read the papers.

508
00:38:41,060 --> 00:38:46,000
And so I went and I read paper after paper and I read dozens and dozens of paper.

509
00:38:46,300 --> 00:38:48,780
And I was particularly fascinated by ivermectin.

510
00:38:48,920 --> 00:38:57,500
Why why this anti parasitic drug was the focus of so much attention in the United States to the point where the FDA is telling people not to take it.

511
00:38:58,100 --> 00:39:06,280
And yet we have, you know, as you as you mentioned, we have decades of of prescriptions given of ivermectin.

512
00:39:06,280 --> 00:39:15,600
I think four billion doses at this point, you know, excellent safety record around the world, unquestionable safety record established around the world.

513
00:39:16,020 --> 00:39:19,360
And yet, why was why was this a focus of such, you know, controversy and attention?

514
00:39:19,360 --> 00:39:34,980
And and as I dove into that research into ivermectin, hydroxychloroquine and so on, I discovered a large body of literature specifically with ivermectin and cancer and ivermectin in the use of cancer.

515
00:39:35,140 --> 00:39:37,260
And I found that very odd and very unusual.

516
00:39:37,260 --> 00:39:44,180
And I and I, of course, you know, I was naturally curious, well, why why would ivermectin work in cancer?

517
00:39:44,400 --> 00:39:45,920
How does it work in cancer?

518
00:39:46,020 --> 00:39:55,620
And so, you know, I did a PubMed search and and I think something like over 300 peer reviewed papers come out.

519
00:39:55,620 --> 00:40:00,920
And and and, you know, in regards to ivermectin and cancer.

520
00:40:01,080 --> 00:40:02,600
Now, it's all preclinical research.

521
00:40:03,100 --> 00:40:05,800
And then you start looking at, well, where are the human trials?

522
00:40:06,000 --> 00:40:07,600
You know, I want to see human trials as well.

523
00:40:07,700 --> 00:40:15,700
But you see preclinical research where they, you know, where they where they're studying the cancer cell lines or they're studying it in mice or rats.

524
00:40:15,700 --> 00:40:22,560
But this preclinical body of research on ivermectin and cancer is so impressive.

525
00:40:22,980 --> 00:40:27,620
It's not one or two papers, you know, some a group of researchers tinkering in the lab.

526
00:40:27,840 --> 00:40:40,920
You know, these are dozens and dozens of paper, you know, extensive research done looking at the various mechanisms of how ivermectin might act in cancer and what cancers ivermectin impact.

527
00:40:40,920 --> 00:40:51,940
And it really seems to be a broad anti-cancer agent that that can be used in a variety of cancers, anything from blood cancers to to solid tumors as well.

528
00:40:52,780 --> 00:41:05,580
And it's it's just such a fascinating it's just such a fascinating molecule, because when you look at the mechanisms of action now, this is an antiparasitic, a very successful antiparasitic.

529
00:41:05,780 --> 00:41:09,080
And yet it has different mechanisms of action in cancer.

530
00:41:09,080 --> 00:41:21,020
It targets cancer stem cells, for example, something that I find really fascinating, where it's able to attack these cancer stem cells that don't necessarily proliferate rapidly.

531
00:41:21,920 --> 00:41:28,880
But, you know, these are cells that could cause problems in the future that could cause metastases in the future that could cause cancer recurrence in the future.

532
00:41:28,880 --> 00:41:41,100
And I and I believe that when you have standard chemotherapy, standard chemotherapy will kill the rapidly dividing cells just based on the nature of the rapid proliferation.

533
00:41:41,100 --> 00:41:44,700
But they will not kill slowly dividing cells often.

534
00:41:45,380 --> 00:41:47,900
And the chemotherapy may not kill cancer stem cells.

535
00:41:48,560 --> 00:41:53,440
And so you often hear chemo being referred to as palliative instead of curative.

536
00:41:53,820 --> 00:42:00,480
The intent is palliative to, you know, the they will tell you you cannot cure stage four pancreatic cancer.

537
00:42:00,640 --> 00:42:03,340
For example, you cannot cure stage four ovarian cancer.

538
00:42:03,340 --> 00:42:10,900
We can buy you time with chemotherapy, which will kill most of the cancer and shrink a lot of the tumors and so on.

539
00:42:11,000 --> 00:42:13,420
But it will not kill the cancer stem cells.

540
00:42:13,640 --> 00:42:21,760
And it will not kill cancer cells that are resistant to that chemo because cancer cells can develop a resistance to certain chemotherapy.

541
00:42:22,020 --> 00:42:25,340
They might have, you know, these pumps that just pump the chemotherapy right out of the cell.

542
00:42:25,340 --> 00:42:32,200
And so in some cases, like ovarian cancer specifically, these tumors can develop a resistance to chemotherapy.

543
00:42:32,440 --> 00:42:36,380
That's why the oncologist has to change the chemo and go to the next agent and so on.

544
00:42:37,220 --> 00:42:41,960
Well, ivermectin can kill cancer stem cells that chemo can't.

545
00:42:42,440 --> 00:42:47,200
Ivermectin can also reverse what's called multidrug resistance in cancer cells.

546
00:42:47,340 --> 00:42:50,960
And so it can actually sensitize cancer cells to chemotherapy.

547
00:42:51,320 --> 00:42:53,360
It's also a radiosensitizer.

548
00:42:53,360 --> 00:42:58,060
It can sensitize cancer cells to radiation therapy, for example, as well.

549
00:42:58,220 --> 00:42:59,280
Now, it has other actions.

550
00:42:59,400 --> 00:43:03,160
It can inhibit the tumor's ability to form new blood vessels.

551
00:43:03,740 --> 00:43:05,540
So it can inhibit angiogenesis.

552
00:43:06,460 --> 00:43:11,440
Ivermectin also inhibits certain enzymes called matrix metalloproteinases,

553
00:43:12,140 --> 00:43:21,080
which are enzymes that detach cancer cells from the tumor and allow it to metastasize and spread to other parts of the body through the bloodstream.

554
00:43:21,080 --> 00:43:29,580
And so ivermectin will actually inhibit those enzymes so that it inhibits metastasis of the tumor, for example.

555
00:43:29,720 --> 00:43:37,400
So when you look at it, there's a dozen different mechanisms by which ivermectin acts on the molecular level on cancers.

556
00:43:37,980 --> 00:43:40,860
And so then you ask the question, where are the human trials?

557
00:43:40,860 --> 00:43:43,160
Because that's what it ultimately comes down to.

558
00:43:43,340 --> 00:43:44,900
Yes, preclinical research is nice.

559
00:43:45,260 --> 00:43:47,260
We have hundreds of papers on ivermectin and cancer.

560
00:43:47,680 --> 00:43:49,060
Where are the human trials?

561
00:43:49,220 --> 00:43:49,980
And there aren't any.

562
00:43:50,440 --> 00:43:51,580
There are case reports.

563
00:43:51,680 --> 00:43:54,360
There's a case series on three patients with leukemia.

564
00:43:55,020 --> 00:44:00,780
I believe two of them were able to achieve some form of remission with ivermectin.

565
00:44:00,780 --> 00:44:02,840
And that's it.

566
00:44:03,040 --> 00:44:06,680
We don't have any randomized controlled trials.

567
00:44:07,000 --> 00:44:09,120
We don't have any large studies in humans.

568
00:44:09,280 --> 00:44:12,940
And then you find out, well, ivermectin has been off patent since the 1990s.

569
00:44:13,460 --> 00:44:14,940
I believe Merck held the patent.

570
00:44:15,620 --> 00:44:17,920
The patent expired in 96, I believe.

571
00:44:18,600 --> 00:44:20,640
And so it's a cheap drug that's off patent.

572
00:44:20,640 --> 00:44:28,580
And then you realize, okay, well, there's no money to be made in studying ivermectin in humans for cancer.

573
00:44:28,580 --> 00:44:34,800
And where there's no money to be made in oncology, tragically, the research just doesn't follow.

574
00:44:35,800 --> 00:44:38,100
And so you see this focus.

575
00:44:38,820 --> 00:44:40,740
And this happens to a lot of repurposed drugs.

576
00:44:40,920 --> 00:44:46,800
And so, for example, you look at something like another antiparasitic, fenbendazole or mebendazole.

577
00:44:46,800 --> 00:44:51,100
Now, this is a different family of antiparasitics than ivermectin.

578
00:44:51,820 --> 00:45:00,400
Fenbendazole was actually interestingly discovered by a terminal cancer patient from Oklahoma, Joe Tippins.

579
00:45:00,820 --> 00:45:07,620
And Joe Tippins had stage 4 small cell lung cancer, which is one of the most aggressive cancers known.

580
00:45:08,340 --> 00:45:13,260
And he had stage 4 small cell lung cancer diagnosis, terminal diagnosis.

581
00:45:13,260 --> 00:45:17,540
And I believe he was put on a trial of Keytruda at the time.

582
00:45:18,680 --> 00:45:20,800
Is that a regular cancer drug?

583
00:45:21,460 --> 00:45:22,820
It is a regular cancer drug, yeah.

584
00:45:24,240 --> 00:45:27,880
And sort of what they call an immune checkpoint inhibitor.

585
00:45:28,140 --> 00:45:28,300
Yeah.

586
00:45:28,300 --> 00:45:35,160
And so he was put on Keytruda, and he tells the story later on that everybody on that trial died.

587
00:45:35,280 --> 00:45:36,480
He was the only one who survived.

588
00:45:36,480 --> 00:45:48,380
And he tells the story of how he had a friend who was a veterinarian who said, look, there's this parasitic drug, this dog dewormer called fenbendazole.

589
00:45:48,860 --> 00:45:52,620
It's been accidentally found to have anti-cancer properties in mice.

590
00:45:53,160 --> 00:45:53,940
It's cheap.

591
00:45:54,120 --> 00:45:55,540
It's safe to take.

592
00:45:55,620 --> 00:45:56,800
Why don't you try it?

593
00:45:56,800 --> 00:46:09,500
And the story goes that he went, he tried this dog dewormer, dog medicine, I guess you could say, and he cured his stage 4 small cell lung cancer, which is completely unheard of.

594
00:46:09,620 --> 00:46:16,220
I think he was given a survival of less than 1%, sort of a five-year survival of less than 1%.

595
00:46:16,220 --> 00:46:17,900
And he's still here to this day.

596
00:46:18,000 --> 00:46:22,840
Seven years later, he's cancer-free with a stage 4 small cell cancer diagnosis.

597
00:46:22,840 --> 00:46:40,880
And so he, at the time, he would actually go on news shows and talk about his experience of trying fenbendazole, which was not FDA-approved for use in humans, and how it cured his, or he believed that it cured his stage 4 cancer.

598
00:46:40,880 --> 00:46:58,360
And then, you know, I look into that research, that body of research, see, again, there's a ton of preclinical research on fenbendazole, and there's now been cases published by Stanford University Medical Center of three patients who cured their stage 4 cancer with fenbendazole.

599
00:46:59,020 --> 00:47:03,720
And the Stanford group looked into it, analyzed it, you know, monitored these patients.

600
00:47:03,800 --> 00:47:07,480
These patients had all failed three or four lines of chemotherapy.

601
00:47:07,480 --> 00:47:14,760
They were terminal, they took fenbendazole, and they are now cancer-free, and the Stanford group published this.

602
00:47:14,820 --> 00:47:23,180
Now, the Stanford group itself, they were not allowed, the researchers were not allowed to recommend that drug, fenbendazole, because it's not FDA-approved.

603
00:47:23,880 --> 00:47:29,920
But they were at least, this is how, this is what I love about science, is that they saw something fascinating,

604
00:47:30,220 --> 00:47:35,820
they saw something that they thought other doctors and scientists should know about, and they published it.

605
00:47:35,820 --> 00:47:38,040
And they published this case here.

606
00:47:38,140 --> 00:47:47,280
You had actually talked about this, you had talked about this paper from 2021, this series of three people who had cured their cancer with fenbendazole.

607
00:47:47,700 --> 00:47:52,300
And so there is an FDA-approved version of fenbendazole called mebendazole.

608
00:47:53,260 --> 00:47:55,160
It's structurally almost identical.

609
00:47:55,860 --> 00:47:59,000
There's one atom difference between fenbendazole and mebendazole.

610
00:47:59,000 --> 00:48:05,700
So, mebendazole has been approved by the FDA as an antiparasitic drug for use in children and adults.

611
00:48:06,380 --> 00:48:10,600
And so it has an incredible safety profile, very safe to use.

612
00:48:11,400 --> 00:48:21,860
And mebendazole actually has a dozen clinical trials in which it's being looked at as a cancer agent, as a repurposed drug for cancer.

613
00:48:21,860 --> 00:48:31,240
And so I think because of its status as an FDA-approved drug, there was much more willingness in the oncology community to do trials with it.

614
00:48:31,300 --> 00:48:35,420
And so there are trials in adults looking at colon cancer and various prostate cancer,

615
00:48:35,540 --> 00:48:39,660
and there's also trials in children looking at brain cancers with mebendazole.

616
00:48:41,220 --> 00:48:46,220
And again, this is an antiparasitic drug that has a dozen mechanisms of action.

617
00:48:46,220 --> 00:48:51,840
One of the fascinating mechanisms of action in cancer is that it blocks glucose transporters on cancer cells.

618
00:48:52,300 --> 00:48:56,980
And so it sort of starves the cancer cell from being able to use glucose as a fuel source.

619
00:48:57,500 --> 00:49:00,340
Specifically in cancer cells and not on normal cells.

620
00:49:00,960 --> 00:49:01,560
Yeah, exactly.

621
00:49:01,960 --> 00:49:03,380
Glucose transporting in cancer cells.

622
00:49:03,800 --> 00:49:04,360
That's amazing.

623
00:49:04,480 --> 00:49:12,640
So there must be something biochemically different about the glucose transporter in cancer cells compared to ordinary cells that it's able to specifically target.

624
00:49:13,280 --> 00:49:13,700
Exactly.

625
00:49:13,700 --> 00:49:18,300
And what's fascinating about these repurposed drugs is they are very specific to cancer cells.

626
00:49:18,480 --> 00:49:24,560
They are able to somehow identify a cancer cell from a normal cell.

627
00:49:24,840 --> 00:49:27,160
And this has been studied in ivermectin as well.

628
00:49:27,520 --> 00:49:32,540
Ivermectin is actually able to identify lymphoma cells and act on them.

629
00:49:32,900 --> 00:49:35,540
And it's able to also identify normal cells.

630
00:49:35,620 --> 00:49:38,720
And it doesn't have that same effect on the normal cells.

631
00:49:40,120 --> 00:49:41,340
It's what we call a magic bullet.

632
00:49:41,340 --> 00:49:44,260
It is absolutely fascinating.

633
00:49:44,700 --> 00:49:49,140
I encourage anyone, look into the preclinical research.

634
00:49:49,420 --> 00:49:51,400
It is absolutely fascinating.

635
00:49:51,400 --> 00:49:59,120
And the mechanisms that we're talking about here, that you're talking about, are based on known biochemical pathways.

636
00:49:59,760 --> 00:50:01,440
This is not something new.

637
00:50:01,580 --> 00:50:03,540
This is understood biochemistry.

638
00:50:03,540 --> 00:50:11,500
And these drugs interfere in a particular biochemical mechanism in a known biochemical way.

639
00:50:11,560 --> 00:50:12,860
This is not speculation.

640
00:50:13,500 --> 00:50:17,200
I mean, biochemistry is basically a hard science.

641
00:50:17,320 --> 00:50:19,100
I mean, medicine's a bit soft around the edges.

642
00:50:19,100 --> 00:50:22,180
But biochemistry is a hard science.

643
00:50:22,320 --> 00:50:23,380
It is bench chemistry.

644
00:50:23,700 --> 00:50:26,280
And you can't really argue with that.

645
00:50:26,700 --> 00:50:31,700
And the fact that it's got multiple mechanisms of action on multiple biochemical pathways.

646
00:50:31,700 --> 00:50:36,040
And that's true for ivermectin and the mabendazole-fenbendazole group.

647
00:50:36,040 --> 00:50:47,160
It's just absolutely incredible that these natural molecules seem to have these multiple modalities of action.

648
00:50:47,360 --> 00:50:51,580
And yet, we're staring the gift to us in the mouth.

649
00:50:51,580 --> 00:50:52,940
Exactly.

650
00:50:53,280 --> 00:50:55,180
And the research is very, very solid.

651
00:50:56,060 --> 00:51:00,800
The research on the mechanisms, the preclinical research is very solid.

652
00:51:01,060 --> 00:51:02,440
This is not one or two papers.

653
00:51:02,940 --> 00:51:04,680
This has been replicated.

654
00:51:05,040 --> 00:51:08,800
This is hundreds of papers for these anti-parasitic drugs.

655
00:51:09,040 --> 00:51:11,560
So this is not a conspiracy theory.

656
00:51:11,760 --> 00:51:14,020
This is not fringe medicine.

657
00:51:14,360 --> 00:51:15,400
Hard science.

658
00:51:15,580 --> 00:51:16,620
It's as hard as it gets.

659
00:51:16,620 --> 00:51:16,840
Absolutely.

660
00:51:16,840 --> 00:51:18,460
This is hard science.

661
00:51:19,940 --> 00:51:25,160
And I love, you know, I'm always fascinated by preclinical research.

662
00:51:25,720 --> 00:51:29,000
Because that is what we stand on.

663
00:51:29,080 --> 00:51:32,880
That is what the rest of medicine stands on is the preclinical research.

664
00:51:33,020 --> 00:51:34,740
That's what we rely on as physicians.

665
00:51:35,020 --> 00:51:37,720
And that's what gives us the plausible mechanisms of action.

666
00:51:37,840 --> 00:51:44,680
Because if you can't give a plausible mechanism of action, well, you're not fulfilling an essential Bradford Hill criteria apart from anything else.

667
00:51:44,680 --> 00:51:51,900
But, you know, if you can say, well, this is the way it's working, then that's what takes you into science away from mumbo jumbo.

668
00:51:52,520 --> 00:52:07,640
Because we've got existing science and this pharmacodynamic effect, the way this drug is working, is dovetailing with what we already know, with multiple points of consistency with what is already known.

669
00:52:07,640 --> 00:52:08,100
That is, to Tot really?

670
00:52:08,100 --> 00:52:08,300
That is good of mine.

671
00:52:08,300 --> 00:52:08,820
Dovetailing with what?

672
00:52:08,820 --> 00:52:09,360
That is good of mine.

673
00:52:09,360 --> 00:52:09,460
Thank you.

674
00:52:09,460 --> 00:52:10,260
That is good of mine.

675
00:52:10,260 --> 00:52:10,760
Yes.

676
00:52:10,780 --> 00:52:11,160
For me.

677
00:52:11,340 --> 00:52:11,980
That is true.

678
00:52:11,980 --> 00:52:12,320
Dr dentists.

679
00:52:12,320 --> 00:52:13,240
No.

680
00:52:13,240 --> 00:52:13,440
That is true.

681
00:52:13,480 --> 00:52:13,980
That is Tants.

682
00:52:14,040 --> 00:52:14,600
Yeah.

683
00:52:14,600 --> 00:52:15,900
That is what you say.

684
00:52:15,900 --> 00:52:16,320
So what you say.

685
00:52:16,900 --> 00:52:18,480
I have the former women 817 year old married to 2 aos 11 years old.

686
00:52:18,480 --> 00:52:20,560
The children 9 20 years old are going to have born the country painting.